SDS

11
CONTINUED: SECTION 11. TOXICOLOGICAL INFORMATION
Carcinogenicity :
IARC
- Nickel : Group 2B
- Cobalt and cobalt compounds : Group 2B
- Polyethylene : Group 3
- Diiron Trioxide : Group 3
- Carbon black : Group 2B
- Chromium : Group 3
- Ethylbenzene : Group 2B
NTP
- Nickel : R
- Iron : Present
- Carbon black : Present
OSHA
- Nickel : Present
- Carbon black : Present
ACGIH
- Nickel : A5
- Aluminum : A4
- Cobalt and cobalt compounds : A3
- Diiron Trioxide : A4
- Carbon black : A3
- Chromium : A4
-Ethylbenzene : A3
KOREA-ISHL
- Lithium Nickel Oxide : 2
- Nickel : 1A
- Cobalt and inorganic compounds : 2
- Carbon black : 2
- Chromium : 1A(Chromium(Ⅵ)compounds(Water insoluble inorganic compounds))
- Ethylbenzene : 2
EU
- Nickel : Carc. 2
- Copper : EPA IRIS: D In carcinogenicity study with rat, tumor was not observed.
- Polyethylene : Fifty rats were implanted with polyethylene. In the polyethylene group, 23 developed tumors (two of these were
unrelated to the implants).
- Boehmite (Al(OH)O) : bauxite and alumina exposure was not associated with increased cancer risk.
- Ethylbenzene : there was clear evidence of carcinogenic activity of ethylbenzene in rat(male/female)with based on increased
Incidences of renal tubule neoplasms; increased incidence of testicular adenoma.
Assay(OECD Guideline 471, GLP)) and Negative reactions were observed in vivo (Mammalian Erythrocyte Micronucleus
Test(OECD Guideline 474, GLP)).
- Dimethyl carbonate : Negative reactions were observed in both in vitro (Mammalian Chromosome Aberration Test (OECD
Guideline 473, GLP)) and in vivo (Mammalian Spermatogonial Chromosome Aberration Test (OECD Guideline 483))
- Polyethylene : Negative reactions were observed in Ames test using Salmonella typhimurium and Escherichia coli.
- Diiron trioxide : Negative reactions were observed in both in vitro (Mammalian Chromosome Aberration Test (OECD Guideline
473, GLP)) and in vivo (DNA damage, chromosome aberration and micronuclei induction test)
- Boehmite (Al(OH)O) : Negative reactions were observed in vitro (mammalian cell gene mutation assay(OECD TG 476, GLP),
Negative reactions were observed in vivo Mammalian Erythrocyte Micronucleus Test(OECD TG 474, GLP)
- Carbon black : Negative reactions were observed in both in vitro(Bacterial gene mutation test(OECD TG 471, GLP), Chromosomal
aberrations test(OECD TG 476)) and in vivo(DNA damage and/or repair test).
-1-Methyl-2-pyrrolidinone : Negative reactions were observed in both in vitro (Chromosomal aberrations test (OECD Guideline 476,
GLP)) and in vivo (Mammalian Erythrocyte Micronucleus Test (OECD Guideline 474, GLP)).
- Chromium : In vitro mammalian chromosome aberration test, the result of the assay was negative. (Read across; stainless
steel)(OECD TG 473, GLP)
- Lithium carbonate;Lithane : Negative reactions were observed in vitro (Bacterial Reverse Mutation Assay(OECD Guideline 471,
GLP)).
- Ethylbenzene : Negative reactions were observed in in vitro-mammalian chromosome aberration test(OECD TG 473), mammalian
cell gene mutation test (OECD TG 476, GLP) and in vivo- unscheduled DNA synthesis (UDS) test with mammalian liver cells
(OECD TG 486, GLP), mammalian erythrocyte micronucleus test (OECD TG 474, GLP).