SDS

Material Safety Data Sheet
Version: 1.6
08/24/2009
M90007
Acetoxy Sanitary Sealant
Page 6/8
days)developed increased liver weights in female animals relative to unexposed control animals.
When the exposure was stopped, liverweights returned to normal. Microscopic examination of the
liver cells did not show any evidence of pathology. Inhalationstudies utililizing laboratory rabbits and
guinea pigs showed no effects on liver weights. Inhalation exposures typical ofindustrial usage (5-10
ppm) showed no toxic effects in rodents. Range finding reproductive studies were conducted (whole
body inhalation, 70 days prior to mating, through mating, gestationand lactation) with
octamethylcyclotetrasiloxane (D4). Rats were exposed to 70 and 700 ppm. In the 700 ppm group,
there wasa statistically significant reduction in mean litter size and in implantation sites. No D4 related
clinical signs were observedin the pups and no exposure related pathological findings were found.
Interim results from a two generation reproductive study in rats exposed to 500 and 700 ppm D4
(whole body inhalation, 70 daysprior to mating, through mating, gestation and lactation) resulted in a
statistically significant decrease in live meanlitter size as well as extended periods of off-spring
delivery (dystocia). These results were not observed at the 70 and 300ppm dosing levels. Preliminary
results from an ongoing 24-month combined chronic/oncogenicity study in rats exposed to 10, 30, 150,
or700 ppm D4 showed test-article related effects in the kidney (male and female) and uterus of rats
exposed for 12 to 24 months. These effects include increased kidney weight and severity of chronic
nephropathy, increased uterine weight,increased incidence of endometrial cell hyperplasia, and an
increased incidence of endometrial adenomas. All of theseeffects are limited to the 700 ppm
exposure group. These results have been shown to be rat-specific. Further studies are ongoing. In
developmental toxicity studies, rats and rabbits were exposed to octamethylcyclotetrasiloxane at
concentrations up to 700 ppmand 500 ppm respectively. No teratogenic effects (birth defects) were
observed in either study.
SENSITIZATION
no data available
SKIN IRRITATION
no data available
EYE IRRITATION
no data available
MUTAGENICITY
Unknown
OTHER EFFECTS OF OVEREXPOSURE
Acetic acid released during curing.
12. ECOLOGICAL INFORMATION
ECOTOXICITY
no data available
DISTRIBUTION
no data available
CHEMICAL FATE
no data available